According to the latest studies regarding healthcare, macrophages can improve the production of progesterone, which, in turn, makes pregnancy possible. The macrophage is a kind of white blood cell which engulfs and digests foreign materials.
What to know about macrophages?
The macrophages play an important role in the activities of the immune system because they are the ones to fight the foreign objects, including pathogens. Their job is to remove and clean out the dying cells and cellular debris. They are usually found in connective tissue, the spleen, and liver.
The findings of the study
The leader of the study has been Professor Sarah Robertson and the main focus area of the study has been infertility. Previous studies were also concerned with macrophages, but this is the first study to demonstrate its necessity for pregnancy.
How does it work?
It is the macrophages’ job to organize the blood vessels in the ovary, thus increasing the progesterone production. If a woman has a low macrophages level, her progesterone levels might not be high enough, leading to poor development of the embryo and increasing the chances of miscarriage.
What do the specialists have to say?
The corpus luteum has to develop at a very fast pace, in a matter of days, in order to produce progesterone. It was surprising to find how much the macrophages contribute to this process by ensuring a healthy vascular system. This was the first time that specialists really understood how the macrophages work.
Low levels of macrophages
According to the findings of the study, the low macrophages levels can be treated by progesterone treatment. There are a lot of women affected by infertility, and in the majority of the cases the problem is caused by low progesterone levels. Understanding the mechanism of macrophages can help increase the chances of conception and decrease the chances of having a miscarriage.
Affecting the macrophages
It has been shown by the study that environmental factors like obesity, stress and infection can lead to inflammatory responses which in turn affect the function and generation of macrophages. This means that these environmental factors all influence the ability of women of getting pregnant and of maintaining a healthy pregnancy.
By having all this understanding of the mechanisms of pregnancy, in the future the specialists will be able to help even more women by offering them nutritional and lifestyle changes, thus improving their fertility.